ABSTRACT
To compare the efficacy of Simvastatin with Atorvastatin in lowering Low Density Lipoprotein Cholesterol [LDL-C] in patients with Hypercholesterolemia in a tertiary care hospital. Prospective, observational, single center study. Department of Medicine, Khyber Teaching Hospital, Peshawar. December 2011 to December 2012. A total of 200 cases having base line fasting LDL-C level of >/= 130 mg/dl and meeting the inclusion criteria were included in the study through both outpatient department [OPD] and admitted patient. After detailed history and clinical examination, all patients were divided randomly into two groups, A and B. Patients in Group A were given Simvastatin 20mg/day and Group B received Atorvastatin 20mg/day. Fasting blood samples were taken from the selected patients in the start of study and after 12 weeks. A total of 200 subjects with a serum LDL-C level >/= 130 mg/dL were included in the study. They were divided into 2 groups randomly, 100 in each group. Each group comprised of 75 male and 25 female. The mean age in group A was 52 years and in group B it was 54 years. The age ranges between 40 years and 73 years. Mean base LDL-C level was 165 mg/dl in group A and 170mg/dl in group B. Simvastatin 20 mg/dl reduced LDL-C level by 26% and Atorvastatin 20mg/dl reduced LDL-C level by 33% after 12 weeks of treatment. Atorvastatin is a more effective drug to reduce serum LDL cholesterol than Simvastatin in the same doses
ABSTRACT
To compare the efficacy of ciprofloxacin with ceftriaxone in the treatment of spontaneous bacterial peritonitis in patients with cirrhosis liver and ascites. This hospital based quasi-experimental study. Department of Medicine, Khyber Teaching Hospital Peshawar. October, 2009 to April, 2010. A total of 200 patients were selected by non-probability purposive sampling method after obtaining an informed consent. Sample size was calculated through WHOS statistical calculator. All the selected patients had clinical and biochemical evidence of cirrhosis liver and spontaneous bacterial peritonitis. Both sexes were included in the selected patients had clinical and biochemical evidence of cirrhosis liver and spontaneous bacterial peritonitis. Both sexes were included in the study. They were randomly divided into two groups; group I was treated with ciprofloxacin and group II was treated with ceftriaxone. 200 patients including 124 males and 76 females with spontaneous bacterial peritonitis were included in the study. 100 patients each were treated with ciprofloxacin and ceftriaxone in the two groups. 82% responded favourably to 5 days course of I/V 200 mg ciprofloxacin and 91% were cured with 5 days therapy of I/V 2gm ceftriaxone. Both ceftriaxone and ciprofloxacin are equally effective in the treatment of spontaneous bacterial peritonitis